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Yun Cheng
Bio
As a passionate and detail-oriented graduate student, I enjoy approaching complex projects with computational biology to reveal the principles that underlie biological function. I was trained with advancement of computational modeling methods with data analysis techniques to understand biological phenomena and health pattern, such as controlling, and exploiting the immune system to treat a range of diseases or reprograming of tumor cell metabolism to terminate metastasis. In the future, I hope I can solve human being’s hard-to-treat diseases, make efforts to new therapeutics, and discover or synthesis high value chemicals that can perform advance improvement in medical care.
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Education
> M.S. in Biomedical Engineering, University of Southern California | 2020-2022
> B.S. in Chemical Engineering, Michigan State University | 2015-2020
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Research Background
July 2019 - Present
Graduate Research Assistant,
University of Southern California, Department of Computational Biology and Bioinformatics
Developing computational approaches to experimentally restrained conformational modeling with the
integration of biophysical and biochemical data within the 3D structural framework.
● Current project: Structure-based discovery of Frizzled GPCR Ligand
September 2019 - June 2020
Research Assistant,
Michigan State University, IQ (The institute for quantitative health science and engineering)
Main Design Area: Protein Engineering, aligns in machine learning aspects of protein engineering in designing
a high binding affinity protein library, evolving strong binders with high specificity using a strategic collection of
small, stable protein scaffolds.
●Previous Project: Affibody interface mutation design. Determine the lists of positions and amino acids that could give rise to the paratope geometries based on a gradient of site-wise diversity.
May 2016 - May 2019
Research Assistant,
Michigan State University,
Department of Microbiology and Genetics
● Complete immunostaining (IHC), such as H&E staining, Trichrome Staining, Brdu Injection and detecting
estruses. Conduct Immunofluorescence quantitative analysis for tumor samples.
● General Surgery on Mammary gland of BALB/c Mice.
● Conduct Polymerase chain reaction (PCR) for Tumor tissue.
● Feed and Palpate BALB/c Mice. Provide appropriate care to all groups animal including setting up new cages
indeed and monitor the weaning cages on a day basis.
● Prepare pre-use chemical solutions in laboratory. Duty of care in relation to hazardous chemicals as a reporter.
● Provide technical documentation, analyzed data, reports, presentations and protocols
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Work Experience
Engineering Tutor
● Provide academic support during the assigned hour. Develop study resources for students and hold exam review sessions.
● Lecture Assistant of EGR 102 Provide homework help on MATLAB and EXCEL software. Lecture Assistant of EGR 100. Provide project help on robotic design and academic writing
Chemistry Lab Technician
● Support of the chemistry teaching laboratories, ensuring that adequate supplies of reagents and equipment for all the teaching laboratories are available.
● Assist in the collection of chemistry laboratory wastes and arrange for temporary storage of wastes
WIE(Women In Engineering) Mentor
● Help First-year Female Engineering Students by academic and career advisory.
● Perform one-on-one mentoring meeting and presentation with Freshmen students for university guidance and academic support.
Awards
● Maurice G. and Sara V. Larian Scholarship Fall 2017 to Spring 2018
● 2018 University of Undergraduate Research Forum
● DSCI 552 Machine Learning for Data Science “Top Student” Badge
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